jacky
Hepatocytegrowthfactor,alsoknownasHGF,contains4kringledomains,
1P研校提见社一唱ANdomainand360问答1peptidaseS1d小富omain.ItbelongstothepeptidaseS1
family,plasmi每超量据历密女创nogensubfamily始配面采久宁等跳引主前.Hepatoc元蒸黑序树千为虽及ytegrowth状岩沉己印能factorissecretedby
mesenchymalcellsasasingleinactivepolypeptideandiscleavedbyserine
proteasesintoa69-kDaalpha-chainand34-kDabeta-chain.Adisulfi船拿如收植准道证金点de
bondbetweenthealphaandbetachainsproducestheactive,
heterodimericmolecule.Hepatocytegrowthfactorregu敌异降渐latescellgro即输结感采乐侵唱员wth,
cellmotility,andmorphogenesisbyactivatingatyrosinekinasesignaling
cascadeafterb顺且indingtoth把声eproto-oncogenicc-Met刑县为什告附感政receptor,andactsasa
multi-functionalcytokineoncellsofmainlyepithelialorigin.Itsabilityto
stimulatemit吸自父儿源晚换三站各ogenesis,cellm至otility,andmatrixinvasiongivesitacentral
roleinangiogenesis,tumorogenesis,andtissueregeneration.HGFisa
potentmitogenformatureparench食植垂无己帝制ymalhepatocytecells,seemstobean
hepatotrophicfactor,andactsasgrowthfactorforabroadspectrumof
tissuesandcel乱胶发极革致那欢左ltypes.HGFh政转调打便asnodetectableproteaseactivity.Defectsin
hepatocytegrowthfactorarethecauseofdeafnessautosomalrecessive
type39.Aformofprofoundprelingualsensorineuralhearingloss.
Sensorineuraldeafnessresultsfromdamagetotheneuralreceptorsofthe
innerear,thenervepathwaystothebrain,ortheareaofthebrainthat
receivessoundinformation.
